A-292 SINGLE INSTITUTION EXPERIENCE IN THE MANAGEMENT OF LOCALLY ADVANCED (pT4) DIFFERENTIATED THYROID CARCINOMAS

Autor:	L Sessa, C De Crea, N Voloudakis, F Pennestri, L Revelli, P Gallucci, L Tagliaferri, G Schinzari, E D Rossi, A Pontecorvi, R Bellantone, M Raffaelli
Rok vydání:	2023
Předmět:	Surgery
Zdroj:	British Journal of Surgery. 110
ISSN:	1365-2168 0007-1323
DOI:	10.1093/bjs/znad100.014
Popis:	Background Locally infiltrating (T4) differentiated thyroid carcinomas (DTC) represent a challenge. Surgical strategy and adjuvant therapy should be planned balancing morbidity and oncologic outcome. A series of T4 DTC who underwent multidisciplinary evaluation and treatment is reported. Methods All DTC cases operated between 2009 and 2021 were reviewed and T4 DTC cases were identified. En bloc resection of inferior laryngeal nerve (ILN), tracheal (TR) and/or internal jugular vein (IJV) was performed in cases of massive infiltration. In case of pharyngoesophageal junction (PEJ) invasion shaving technique was always chosen. Results Among 4775 DTC cases, 60 (1.25%) were T4. ILN infiltration was documented in 45 cases (75% - en bloc resection in 9), TR infiltration in 14 (23.3% - tracheal resection in 2), PEJ invasion in 11 (18.3% - in 7 cases R0 resection, in 4 cases Conclusion Multidisciplinary approach is essential for the management of T4 DTC. Individualised and balanced surgical strategy and adjuvant treatments, in particular EBRT, ensure control of locally advanced disease with acceptable morbidity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0077e40321dac62a520009813431a853 https://doi.org/10.1093/bjs/znad100.014 Zobrazit plný text záznamu