Stability and Therapeutical Efficacy of Allopurinol Gargle

Autor:	Masako Muroi, Yasuko Tanina, Norie Masaki, Genshin Tei, Jun Nakamura, Hiroko Yoshigami, Tomiko Ohtani, Yoshikazu Sakagami
Rok vydání:	1992
Předmět:	musculoskeletal diseases congenital hereditary and neonatal diseases and abnormalities medicine.medical_specialty integumentary system business.industry Internal medicine medicine nutritional and metabolic diseases Allopurinol Pharmacology business Gastroenterology medicine.drug
Zdroj:	Japanese Journal of Hospital Pharmacy. 18:510-515
ISSN:	2185-9477 0389-9098
DOI:	10.5649/jjphcs1975.18.510
Popis:	The chemical stability and the microbial numbers of non-sterilized and sterilized 0.1% allopurinol gargle (allopurinol gargle) were studied.Furthermore, studied the efficacy for some patients who were afflicted with oral mucositis.Allopurinol gargle (0.1%) was chemically stable under the storage in the room temperature or in the refrigerator at least for 15 days. Bacterial numbers in the non-sterilized samples increased at regular interval, while the sterilized sample wasn't detected the bacterial colonies for 15 days. On the therapeutical efficacy of allopurinol gargle for 8 patients, all 8 cases were judged effective.However, we think that more modification to the allopurinol gargle preparation and more clinical data would be needed.
Databáze:	OpenAIRE
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