Cytomegalovirus Infection and Pneumonitis: Impact after Isolated Lung Transplantation
| Autor: | Edward L. Spitznagel, Carolyn M. Dresler, Neil A. Ettinger, Thomas C. Bailey, Joel D. Cooper, Elbert P. Trulock, Raab S, D J Anderson, Gregory A. Storch |
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| Rok vydání: | 1993 |
| Předmět: |
Pulmonary and Respiratory Medicine
Human cytomegalovirus Ganciclovir biology medicine.diagnostic_test business.industry medicine.medical_treatment Respiratory disease virus diseases respiratory system medicine.disease biology.organism_classification respiratory tract diseases Pneumonia Bronchoalveolar lavage Betaherpesvirinae Immunology medicine Lung transplantation business Pneumonitis medicine.drug |
| Zdroj: | American Review of Respiratory Disease. 147:1017-1023 |
| ISSN: | 0003-0805 |
| Popis: | Using aggressive surveillance of blood, bronchoalveolar lavage (BAL) fluid, and lung tissue, we sought to determine the incidence of cytomegalovirus (CMV) pneumonitis in isolated lung transplant recipients and to characterize its impact on pulmonary function, chronic rejection, and survival. Forty-six lung transplant recipients who survived greater than 30 days had prospective documentation of CMV infection in blood and BAL fluid and regular surveillance with transbronchial lung biopsy. CMV infection was documented in 92% of patients who were D−/R+, D+/R+, or D+/R−, and the incidence of historically confirmed CMV pneumonitis among these patients was 75%. No D−/R− patient experienced CMV infection or disease. D+/R− patients experienced more frequent and severe episodes, and ganciclovir prophylaxis during the first 2 wk was not useful. CMV pneumonitis was accompanied by detectable radiographic changes in less than one third of cases. The detection of CMV in BAL fluid was not predictive of CMV pneumonitis on... |
| Databáze: | OpenAIRE |
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