Utilidad del verapamil en el tratamiento de la disfunción diastólica de pacientes acromegálicos
| Autor: | Climent Payá Ve, Marín Ortuño F, Sogorb Garri F, Martínez Martínez Jg, Sánchez Payá J, Picó Alfonso Am |
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| Rok vydání: | 2003 |
| Předmět: | |
| Zdroj: | Revista Clínica Española. 203:15-19 |
| ISSN: | 1578-1860 0014-2565 |
| DOI: | 10.1157/13042183 |
| Popis: | Introduction Diastolic dysfunction is a common complication in patients with acromegaly. By using the metabolic treatment for acromegaly, an improvement in diastolic function is not always achieved and a group of these patients could obtain some benefit from a specific treatment for such a condition. The objective of the present study was to evaluate the utility of verapamil therapy in acromegalic patients with diastolic dysfunction. Methods Fourteen patients (7 males and 7 females) with the diagnosis of acromegaly and diastolic dysfunction confirmed by echocardiogram were studied. After six months of treatment with verapamil (240 mg/day) the echo-cardiographic parameters and the functional class (NYHA) of patients were reevaluated. Results All patients showed an increased basal measurement of the cardiac mass (mean [percentiles 25-75]: 149 g/m2 [128-264]) and no improvement was observed after treatment (182 g/m2 [123-328]). Also, no improvement was found regarding the studied diastolic function parameters: E/A relationship of left ventricle (0.70 [0.54-0.83] versus 0.61 [0.54-0.86]) and isovolumetric relaxation time (146 [119-193] versus 120 [97-169]). A trend towards improvement was indeed found in the functional class, although no statistical differences were observed. Conclusion Our results did not demonstrate a benefit derived from the treatment with verapamil upon the diastolic function in patients with acromegaly. |
| Databáze: | OpenAIRE |
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