Impact of L-Carnitine on Bisphenol A-Induced Kidney Damage in Rats
| Autor: | Mohamed A. Lebda, Nabil M. Taha, Abd El-Wahab A. Mandour, Hanan A. Edres |
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| Rok vydání: | 2018 |
| Předmět: |
endocrine system
medicine.medical_specialty Antioxidant medicine.medical_treatment Renal function medicine.disease_cause 01 natural sciences 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Carnitine Kidney urogenital system 010405 organic chemistry business.industry General Medicine Glutathione Malondialdehyde 0104 chemical sciences Endocrinology medicine.anatomical_structure chemistry Toxicity business hormones hormone substitutes and hormone antagonists Oxidative stress 030215 immunology medicine.drug |
| Zdroj: | Alexandria Journal of Veterinary Sciences. 56:11 |
| ISSN: | 1110-2047 |
| Popis: | The present study aimed to explore the protective effects of L-carnitine on the oxidative stress induced by Bisphenol A (BPA) in rat kidneys. Forty male adult rats were allocated into four groups (10 rats each); placebo, BPA (50 mg/kg bwt per os), L-carnitine (500 mg/kg bwt i.p), and the BPA/L-carnitine-treated group. After 70 days, blood and kidneys were collected for measurement of renal function, oxidative/antioxidative status, histopathological analyses, and gene expression of nrf2. BPA significantly increased serum urea and carnitine levels suggesting renal damage evidenced by hydropic degenerative changes and hydronephrosis. The level of malondialdehyde (MDA) in kidney was elevated along with decline in renal total antioxidant capacity (TAC) and reduced glutathione (GSH) concentrations following challenged with BPA. Notably, the expression of nrf2 mRNA transcript in kidney tissues was down-regulated after BPA-induced toxicity. L-carnitine treatment ameliorates the damaged effects of BPA on kidneys as indicated by low levels of serum urea and carnitine, and renal MDA. Further, L-carnitine enhances the antioxidants (TAC, and GSH), with up-regulation of nrf2 expression in kidney tissues. Our results suggest the renoprotective activity of L-carnitine in BPA-induced kidney injuries through induction of antioxidant system and modulation of oxidative stress |
| Databáze: | OpenAIRE |
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