Antimycotic Activity and Acute Toxicity of Benzopyranopyrans and Related Compounds

Autor:	Ghassan Al-Johari, Mustafa Abu-Lisan, Mary J. Meegan, Tahsin M. Al-Nakib
Rok vydání:	1990
Předmět:	Cryptococcus neoformans General Medicine Biology biology.organism_classification In vitro Acute toxicity Microbiology Tolnaftate chemistry.chemical_compound Isoconazole chemistry Trichosporon cutaneum medicine Miconazole Candida albicans medicine.drug
Zdroj:	Medical Principles and Practice. 2:221-227
ISSN:	1423-0151 1011-7571
DOI:	10.1159/000157368
Popis:	A series of 39 new benzopyranopyrans and related compounds were synthesised and their antimycotic activity in vitro was evaluated against 4 species of human pathogenic yeasts which were insensitive to miconazole, isoconazole and tolnaftate. The minimum inhibitory concentrations (MICs) of these commercial compounds ranged between 50 and 150 µg/ml. Of the new compounds, 15 were active against 5 strains of Cryptococcus neoformans, while 9 more were active against 3 of these strains with an MIC of 6 µg/ml or lower. Similar MICs were shown by 5 compounds which were active against Candida albicans and 3 which were active against Trichosporon cutaneum. All the active compounds were found to be less toxic than the 3 commercial antimycotics, as judged by their LD50 values in mice. A number of deductions were made regarding the structural variations which resulted in the heterogeneity of response shown by the strains of C. neoformans tested in this series.
Databáze:	OpenAIRE
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