Elevation of intestinal substance P by acute acetic acid in rabbits: Modification by infant formulas

Autor:	Arco Y. Jeng, M. E. Becerra, Mark J.S. Miller, H. Sadowska-Krowicka, X. J. Zhang, D. J. Albrecht, David A. Clark, M. Wong
Rok vydání:	1992
Předmět:	Pharmacology medicine.medical_specialty Chemistry Immunology Ileum Substance P Breast milk Small intestine Hydrolysate Acetic acid chemistry.chemical_compound Endocrinology medicine.anatomical_structure Infant formula Casein Internal medicine medicine Pharmacology (medical)
Zdroj:	Inflammopharmacology. 1:353-362
ISSN:	1568-5608 0925-4692
DOI:	10.1007/bf02755885
Popis:	To determine if infant formulas affect the enteric neuronal response to gut injury, we quantified, in anaesthetized rabbits, the time-dependent increase in intestinal substance P (SP) content in response to luminal acetic acid alone and in combination with various infant formulas. Loops of distal small intestine received by transmural injection, either saline or acetic acid (200 mmol/L) + calcium gluconate (50 mg/ml), alone or in combination with three infant formulas which differed in protein and lipid composition. Intestinal SP was extracted in boiling HCl (0.1 mol/L); levels were quantified by radioimmunoassay in a double blind manner. Acetic acid treatment for 45 min did not affect SP content; however, a significant increase (24–47%) was observed after 3 h (p
Databáze:	OpenAIRE
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