Inhaled all-trans retinoic acid in an individual with severe emphysema
| Autor: | S Mamidi, David A. Lomas, P Kroneberg, Matthias Wjst, G. Kassner, K Pukelsheim, Marion Frankenberger, Löms Ziegler-Heitbrock, Irene Heimbeck, A Fertl, M Neiswirth, Karl Häussinger, P Iadarola, Winfried Möller, David Halsall |
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| Rok vydání: | 2009 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Creatinine Pathology Lung Isoprostane Inhalation business.industry Interleukin respiratory system Gastroenterology respiratory tract diseases Desmosine Excretion chemistry.chemical_compound medicine.anatomical_structure chemistry Internal medicine medicine Formoterol business medicine.drug |
| Zdroj: | European Respiratory Journal. 34:1487-1489 |
| ISSN: | 1399-3003 0903-1936 |
| DOI: | 10.1183/09031936.00105309 |
| Popis: | To the Editors: A patient with extensive emphysema was treated with liposomal all-trans retinoic acid (ATRA) using a controlled inhalation manoeuvre. After a gradual increase from 0.1 mg to 3 mg ATRA per day, the patient was treated at a level of 1 mg·day−1 for 4 days per week. Over the 6-month observation period there was an improvement of forced expiratory volume in 1 s (FEV1) from 16% to 21% predicted and an increase from 400 m to 615 m in the 6-min walking test (6MWT), although there was no apparent change in lung morphology with high-resolution computed tomography (HRCT). Biochemical analysis demonstrated a decrease in exhaled isoprostane and a decrease in serum interleukin (IL)-13. In addition, desmosine excretion decreased from 115 μg·g−1 creatinine to |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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