Curing the historically incurable: treatment success with ledipasvir/sofosbuvir for chronic hepatitis C virus in a heavily treatment-experienced individual

Autor: M. M. Davis, Steven W. Johnson, L. M. Stever, D. H. Priest
Rok vydání: 2016
Předmět:
Zdroj: Journal of Clinical Pharmacy and Therapeutics. 41:727-729
ISSN: 0269-4727
Popis: SummaryWhat is known and objective Significant progression in the treatment of chronic hepatitis C virus has been made with the introduction of direct-acting antivirals (DAAs). However, limited data are available for the retreatment of individuals who have failed multiple prior DAAs. Case description We report a single case of an individual who was unsuccessfully treated with five prior hepatitis C virus treatment regimens including simeprevir plus sofosbuvir who was successfully cured after treatment with ledipasvir/sofosbuvir. What is new and conclusion Ledipasvir/sofosbuvir may be an option for treating patients who have failed multiple prior DAA regimens; however, further research is warranted.
Databáze: OpenAIRE
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