Curing the historically incurable: treatment success with ledipasvir/sofosbuvir for chronic hepatitis C virus in a heavily treatment-experienced individual
Autor: | M. M. Davis, Steven W. Johnson, L. M. Stever, D. H. Priest |
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Rok vydání: | 2016 |
Předmět: |
Pharmacology
Ledipasvir Simeprevir medicine.medical_specialty Sofosbuvir business.industry Hepatitis C virus medicine.disease_cause Virus Treatment experienced Surgery 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine chemistry Chronic hepatitis Internal medicine Medicine LEDIPASVIR/SOFOSBUVIR 030211 gastroenterology & hepatology Pharmacology (medical) 030212 general & internal medicine business medicine.drug |
Zdroj: | Journal of Clinical Pharmacy and Therapeutics. 41:727-729 |
ISSN: | 0269-4727 |
Popis: | SummaryWhat is known and objective Significant progression in the treatment of chronic hepatitis C virus has been made with the introduction of direct-acting antivirals (DAAs). However, limited data are available for the retreatment of individuals who have failed multiple prior DAAs. Case description We report a single case of an individual who was unsuccessfully treated with five prior hepatitis C virus treatment regimens including simeprevir plus sofosbuvir who was successfully cured after treatment with ledipasvir/sofosbuvir. What is new and conclusion Ledipasvir/sofosbuvir may be an option for treating patients who have failed multiple prior DAA regimens; however, further research is warranted. |
Databáze: | OpenAIRE |
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