A randomized controlled trial of calcium with vitamin D, alone or in combination with intravenous pamidronate, for the treatment of low bone mineral density associated with Crohn's disease
| Autor: | D J Rawlings, Nick P Thompson, R. Peaston, Roger M. Francis, Sarah A. Bartram |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
musculoskeletal diseases
Bone mineral medicine.medical_specialty Hepatology Bone density Bone disease business.industry medicine.medical_treatment Osteoporosis Gastroenterology Pamidronic acid chemistry.chemical_element Bisphosphonate Calcium medicine.disease Surgery chemistry Internal medicine Vitamin D and neurology medicine Pharmacology (medical) business medicine.drug |
| Zdroj: | Alimentary Pharmacology & Therapeutics. 18:1121-1127 |
| ISSN: | 0269-2813 |
| DOI: | 10.1111/j.1365-2036.2003.01794.x |
| Popis: | Summary Background : Osteoporosis is a common complication of Crohn's disease. Aim : To study the effect on the bone mineral density of a bisphosphonate (pamidronate) given intravenously, in combination with oral calcium and vitamin D supplements, compared with oral calcium and vitamin D supplements alone. Methods : Seventy-four patients with Crohn's disease and low bone mineral density at the lumbar spine and/or hip were randomized to receive either a daily dose of 500 mg of calcium with 400 IU of vitamin D alone or in combination with four three-monthly infusions of 30 mg of intravenous pamidronate over the course of 12 months. The main outcome measure was the change in bone mineral density at the lumbar spine and hip, measured by dual X-ray absorptiometry, at baseline and 12 months. Results : Both groups gained bone mineral density at the lumbar spine and hip after 12 months. There were significant (P |
| Databáze: | OpenAIRE |
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