| Autor: |
null Mirel Cabrera, null Alejandra Medrano, null Nicole Lecot, null Marcelo Fernandez, null Maria Moreno, null Jose A Chabalgoity, null Juan Pablo Gambini, null Omar Alonso, null Henia Balter, null Pablo Cabral |
| Rok vydání: |
2013 |
| Předmět: |
|
| Zdroj: |
Journal of Analytical Oncology. 2:1-9 |
| ISSN: |
1927-7229 |
| DOI: |
10.6000/1927-7229.2013.02.01.1 |
| Popis: |
Purpose: To study surface technetium labeling of stealth DTPA-Liposomeand to evaluate its potential as a molecular imaging tracer for both normal and melanoma-bearing mice. The radiolabeling yield of liposomes was greater than 90%and showed good chemical and biological stability. Biodistribution studies in normal mice showed blood clearance with hepatic and renal depuration. Melanoma-bearing mice showed a similar pattern of biodistribution with high tumor uptake allowing tumor imaging. The developed method of surface radiolabeled DTPA-PEG-Liposomes with 99mTc was effective and stable in vivo. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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