HLA-DR and DQ polymorphisms in bullous pemphigoid from northern China
| Autor: | M Barnardo, X.-J. Zhu, N. Zhai, F. Song, Susan V. Fuggle, S. Winsey, H.-D. Chen, Xing-Hua Gao, Fenella Wojnarowska, G. Li |
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| Rok vydání: | 2002 |
| Předmět: |
musculoskeletal diseases
endocrine system diseases HLA-DQ Antigen business.industry Haplotype Case-control study Autoantibody Dermatology medicine.disease immune system diseases Immunology Genotype Genetic predisposition medicine Bullous pemphigoid skin and connective tissue diseases business Allele frequency |
| Zdroj: | Clinical and Experimental Dermatology. 27:319-321 |
| ISSN: | 0307-6938 |
| DOI: | 10.1046/j.1365-2230.2002.01037.x |
| Popis: | Bullous pemphigoid (BP) is an autoimmune disease mediated by autoantibodies against hemidesmosome components. This study used PCR-sequence-specific primers to genotype polymorphisms in HLA-DR and DQ in 25 BP patients and 57 normal controls from northern China. We found lower frequencies of DRB1*08 (DR8) and DRB1*08/DQB1*06 (DR8/DQ6) haplotypes in BP patients than in controls (4.08% vs. 15.19% and 1.54% vs. 13.82%, respectively; P < 0.05), suggesting a protective role for DR8 and DR8/DQ6 haplotypes in BP patients from northern China; there were no statistical differences among other alleles tested. This result is strikingly different from previous reports that DQB1*0301 is associated with BP in Caucasian patients and DRB1*1101, DQB1*0302, DRB1*04/DQA1*0301/DQB1*0302 and DRB1*1101/ DQA1*0505/DQB1*0302 with Japanese BP patients. Ethnic differences in the polymorphic composition of the HLA-DR and DQ genes may influence genetic susceptibility to BP. |
| Databáze: | OpenAIRE |
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