The effects of high-energy protons and carbon ions (12C) on the cognitive function and the content of monoamines and their metabolites in peripheral blood in monkeys
| Autor: | V. S. Kudrin, B. A. Lapin, A. S. Shtemberg, O. N. Vasil’eva, A. M. Nosovskii, Gennady N. Timoshenko, Yu. V. Gordeev, Evgeny Krasavin, A. S. Bazyan, A. G. Belyaeva, V. B. Narkevich |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Metabolite chemistry.chemical_element Biochemistry Ion 03 medical and health sciences Cellular and Molecular Neuroscience chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Irradiation Molecular Biology biology biology.organism_classification Peripheral blood Rhesus macaque 030104 developmental biology Monoamine neurotransmitter Endocrinology chemistry Serotonin Neuroscience Carbon 030217 neurology & neurosurgery |
| Zdroj: | Neurochemical Journal. 11:168-175 |
| ISSN: | 1819-7132 1819-7124 |
| Popis: | Model experiments using monkeys (rhesus macaque monkeys) were performed to investigate the neurobiological effects of two components of galactic cosmic radiation, namely, high-energy protons and carbon (12C) ions. It has been demonstrated that the irradiation of a monkey’s head with protons at a dose of 3 Gy did not cause any significant changes in the animal’s cognitive function and in the concentrations of monoamines and their metabolites in the peripheral blood. However, exposure to carbon ions at a dose of 1 Gy resulted in a significant cognitive function impairment and a significant decrease in serotonin metabolite concentrations in the blood in the monkeys with the excitable imbalanced type of higher nervous activity. |
| Databáze: | OpenAIRE |
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