Effect of lincomycin treatment on intestinal microflora composition and its bile-acid-metabolizing activity

Autor:	Enrica Canzi, Annamaria Ferrari, Anna Ceccarelli, Edoardo Fesce, N. Pacini
Rok vydání:	1985
Předmět:	Bile acid medicine.drug_class Microorganism Antibiotics General Medicine Biology biology.organism_classification Applied Microbiology and Biotechnology Microbiology Lincomycin fluids and secretions Antibiotic therapy Lactobacillus medicine Composition (visual arts) Feces medicine.drug
Zdroj:	Current Microbiology. 12:1-4
ISSN:	1432-0991 0343-8651
DOI:	10.1007/bf01567743
Popis:	We have attempted to determine the influence of lincomycin treatment by oral route on the qualitative and quantitative composition of intestinal microflora and on its activity in deconjugating and 7α-dehydroxylating bile acids. Fresh feces from ten patients without preexisting bowel disease were analyzed before and after antibiotic therapy. Our results show that, after antibiotic therapy, the number of microorganisms that 7α-dehydroxylate cholic and chenodeoxycholic acids was greatly decreased, whereas no significant alteration was observed in the total count of microorganisms deconjugating taurocholic and glycocholic acids.Bacteroidaceae and bifidobacteria were almost completely eliminated, and lactobacilli and coliforms were significantly reduced, whereas the number of anaerobic microorganisms was virtually unaffected.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0024e082179cee053015d31c3ddbe484 https://doi.org/10.1007/bf01567743 Zobrazit plný text záznamu Full text from SpringerLink