Tandem Aza-Michael-Condensation-Aldol Cyclization Reaction: Approach to the Construction of DE Synthon of (±)-Camptothecin

Autor:	Uttam R. Kalkote, Subhash P. Chavan, Abasaheb N. Dhawane
Rok vydání:	2008
Předmět:	Tandem Chemistry Organic Chemistry Synthon Ring (chemistry) Combinatorial chemistry chemistry.chemical_compound Aldol reaction Intramolecular force medicine Organic chemistry Reformatsky reaction Derivative (chemistry) Camptothecin medicine.drug
Zdroj:	Synlett. 2008:2781-2784
ISSN:	1437-2096 0936-5214
DOI:	10.1055/s-0028-1083539
Popis:	An efficient synthesis of the DE ring of camptothecin, employing a Reformatsky and a tandem one-pot, three-step trans- formation involving aza-Michael reaction, condensation with ethyl malonyl chloride followed by intramolecular 'aldol' reaction to fur- nish the dihydropyridone derivative from commercially available starting materials, has been achieved.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::001bb8048a183d679c3a6cfe261bcd9b https://doi.org/10.1055/s-0028-1083539 Zobrazit plný text záznamu