Prognostic value of anthropometric measures extracted from whole-body CT using deep learning in patients with non-small-cell lung cancer
| Autor: | Simon Jégou, Frederic Pigneur, Emmanuel Itti, Paul Blanc-Durand, Luca Campedel, Sébastien Mulé, Alain Luciani |
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| Rok vydání: | 2020 |
| Předmět: |
Oncology
Body surface area medicine.medical_specialty Univariate analysis Multivariate analysis business.industry medicine.medical_treatment General Medicine Anthropometry medicine.disease 030218 nuclear medicine & medical imaging Radiation therapy 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis Internal medicine medicine Radiology Nuclear Medicine and imaging In patient Non small cell Radiology Lung cancer business |
| Zdroj: | European Radiology. 30:3528-3537 |
| ISSN: | 1432-1084 0938-7994 |
| Popis: | The aim of the study was to extract anthropometric measures from CT by deep learning and to evaluate their prognostic value in patients with non-small-cell lung cancer (NSCLC). A convolutional neural network was trained to perform automatic segmentation of subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT), and muscular body mass (MBM) from low-dose CT images in 189 patients with NSCLC who underwent pretherapy PET/CT. After a fivefold cross-validation in a subset of 35 patients, anthropometric measures extracted by deep learning were normalized to the body surface area (BSA) to control the various patient morphologies. VAT/SAT ratio and clinical parameters were included in a Cox proportional-hazards model for progression-free survival (PFS) and overall survival (OS). Inference time for a whole volume was about 3 s. Mean Dice similarity coefficients in the validation set were 0.95, 0.93, and 0.91 for SAT, VAT, and MBM, respectively. For PFS prediction, T-stage, N-stage, chemotherapy, radiation therapy, and VAT/SAT ratio were associated with disease progression on univariate analysis. On multivariate analysis, only N-stage (HR = 1.7 [1.2–2.4]; p = 0.006), radiation therapy (HR = 2.4 [1.0–5.4]; p = 0.04), and VAT/SAT ratio (HR = 10.0 [2.7–37.9]; p |
| Databáze: | OpenAIRE |
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