Effects of high-fat diet and fructose-rich diet on obesity, dyslipidemia and hyperglycemia in the WBN/Kob-Leprfa rat, a new model of type 2 diabetes mellitus
| Autor: | Yuki Nakamura, Ayaka Watanabe, Mitsuyuki Shirai, Dai Nagakubo, Junichi Namekawa, Yoshiichi Takagi, Kaoru Wakabayashi, Fumitoshi Asai |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty General Veterinary business.industry nutritional and metabolic diseases Type 2 Diabetes Mellitus 030209 endocrinology & metabolism Fructose Metabolism Type 2 diabetes Carbohydrate metabolism medicine.disease Obesity 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine Endocrinology chemistry Internal medicine Diabetes mellitus Medicine business Dyslipidemia |
| Zdroj: | Journal of Veterinary Medical Science. 79:988-991 |
| ISSN: | 1347-7439 0916-7250 |
| Popis: | Obesity and type 2 diabetes mellitus (T2DM) are occurring at epidemic-like rates, and these epidemics appear to have emerged largely from changes in daily diet. In the present study, we compared effects of high-fat diet (HFD) and fructose-rich diet (FRD) in WBN/Kob-Leprfa (WBKDF) rats that spontaneously develop obesity, dyslipidemia and T2DM. After a 4-week feeding of each diet, WBKDF-HFD and WBKDF-FRD rats exhibited aggravated obesity and dyslipidemia compared with WBKDF rats fed standard diet (STD). In contrast, hyperglycemia developed in WBKDF-STD rats was significantly inhibited in WBKDF-FRD rats, but not in WBKDF-HFD rats. The present study demonstrated that the 4-week feeding of HFD and FRD caused diet-induced obesity with a distinct phenotype in the glucose metabolism in WBKDF rats. |
| Databáze: | OpenAIRE |
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