Regulatory T cells in pregnancy. IV. Genetic characteristics and mode of action of early MLR suppressive T cell subpopulations

Autor:	G Chaouat, G A Voisin
Rok vydání:	1981
Předmět:	Immunology Immunology and Allergy
Zdroj:	The Journal of Immunology. 127:1335-1339
ISSN:	1550-6606 0022-1767
DOI:	10.4049/jimmunol.127.4.1335
Popis:	The genetic characteristics, surface markers, and mechanisms of action of early-acting, mitomycin-resistant, MLR suppressor T cells from multiparous mouse spleens were studied in MLR of various strain combinations. The cell activity appears to be genetically restricted at the suppressor/reactive cell level, and the major restriction occurs via the IC subregion. However, C3H.OL recombinant pointed toward a possible minor requirement for S-G subregion syngenicity. The suppressor T cell was characterized as an Ia+, Ly1-, Ly2+ subset. The use of Karush double chambers as well as of supernatants of regulated MLR provided evidence that the suppressor cells act via soluble product(s).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::000e483e2b0df1354fc83086f38e4caa https://doi.org/10.4049/jimmunol.127.4.1335 Zobrazit plný text záznamu