Radiologic Assessment of Muscle and Fat Stores in Long-Term Type I Diabetics Referred for Pancreas Transplant Compared to Healthy Controls
| Autor: | Santosh Nagaraju, Jason P. Davis, Weston J. Bush, Jonathan A. Fridell, Richard S. Mangus, Tyra A Salisbury, John A. Powelson |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
musculoskeletal diseases
Pharmacology congenital hereditary and neonatal diseases and abnormalities medicine.medical_specialty Type 1 diabetes medicine.diagnostic_test business.industry Skeletal muscle 030209 endocrinology & metabolism Computed tomography 030204 cardiovascular system & hematology Muscle mass medicine.disease Gastroenterology 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Internal medicine Sarcopenia Internal Medicine medicine Sarcopenic obesity Pancreas business Body mass index |
| Zdroj: | Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 13:2989-2995 |
| ISSN: | 1178-7007 |
| Popis: | Type 1 diabetes (DM1) is associated with loss of skeletal muscle and bone mass and may affect body fat stores. This study employs computed tomography (CT) scans to assess the body composition of DM1 patients referred for pancreas transplant compared to healthy controls. A 1:1 case-control design matched study patients with otherwise healthy patients from the trauma database. Matching criteria included age ± 5 years, gender, and body mass index (BMI) ± 2kg/m2. Nutrition variables included serum albumin and protein levels, BMI, and CT measures of muscle mass and fat stores. There were 22 subjects and 22 controls (median DM1 duration 24 years). DM1 patients had less muscle mass and less subcutaneous fat but no difference in visceral fat. Patients with the greatest muscle deficit were those with DM1 greater than 20 years and those younger than age 40. DM1 patients maintain similar BMI and protein levels compared to healthy controls but have marked deficits of muscle and subcutaneous fat. These results inform the nutritional management of DM1 patients and quantify the muscle and fat deficits present in these patients. At highest risk are young patients and those with duration of DM1 over 20 years. |
| Databáze: | OpenAIRE |
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