Increased uterine prostaglandin E receptors in menorrhagic women
| Autor: | R. R. Macdonald, M. K. Mason, Jane Thorogood |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Gynecology
medicine.medical_specialty Progestogen business.industry Obstetrics medicine.medical_treatment Significant difference Obstetrics and Gynecology medicine.disease law.invention Radiation therapy Randomized controlled trial law Carcinoma Medicine business Receptor Survival rate Prostaglandin E |
| Zdroj: | BJOG: An International Journal of Obstetrics and Gynaecology. 95:166-174 |
| ISSN: | 1471-0528 1470-0328 |
| DOI: | 10.1111/j.1471-0528.1988.tb06847.x |
| Popis: | A randomized trial was arranged in Yorkshire to assess whether progestogens would improve survival as part of the primary treatment of endometrial carcinoma, in conjunction with surgery and radiotherapy. A total of 429 patients was randomized on diagnosis to the progestogen or control group and treated locally according to an agreed protocol. All the patients are now more than 1 year after operation and over half are more than 5 years after operation. The projected overall 5-year survival rate is 76% but contrary to expectation there is no statistically significant difference in survival between the patients treated with progestogens and the control group even after statistical adjustment for known prognostic factors. |
| Databáze: | OpenAIRE |
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