Hyaluronic acid (hyaluronan): a review
| Autor: | Jiri Necas, P. Brauner, L Bartošíková, J. Kolar |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
0301 basic medicine
chemistry.chemical_classification General Veterinary Vitreous Fluid Metabolism engineering.material Biology biology.organism_classification 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology Enzyme chemistry Biochemistry Hyaluronic acid engineering Synovial fluid Biopolymer Integral membrane protein Bacteria |
| Zdroj: | Veterinární medicína. 53:397-411 |
| ISSN: | 1805-9392 0375-8427 |
| DOI: | 10.17221/1930-vetmed |
| Popis: | Hyaluronic acid (HA) is a high molecular weight biopolysacharide, discovered in 1934, by Karl Meyer and his assistant, John Palmer in the vitreous of bovine eyes. Hyaluronic acid is a naturally occurring biopolymer, which has important biological functions in bacteria and higher animals including humans. It is found in most connective tissues and is particularly concentrated in synovial fluid, the vitreous fluid of the eye, umbilical cords and chicken combs. It is naturally synthesized by a class of integral membrane protein s called hyaluronan synthases, and degraded by a family of enzymes called hyaluronidases. This review describes metabolisms, different physi - ological and pathological functions, basic pharmacological properties, and the clinical use of hyaluronic acid. |
| Databáze: | OpenAIRE |
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