| Autor: |
Aki Yoda, Hiroshi Saito, Yoshiro Toma, Yukiko Shimizu, Katufumi Otsuki, Takumi Yanaihara |
| Rok vydání: |
1998 |
| Předmět: |
|
| Zdroj: |
Advances in Lactoferrin Research ISBN: 9781475790702 |
| DOI: |
10.1007/978-1-4757-9068-9_33 |
| Popis: |
Lactoferrin (Lf) has been found in most biological fluids including amniotic fluid and cervical mucoids in pregnant women, and released from neutrophils in response to the inflammation. As Lf possesses antimicrobial properties, it is widely considered to be an important component of the host defence against microbial infections. It is known that premature labor is caused by amniotic infection with the increase of prostaglandin production. High concentration of the inflammatory cytokines: interleukin-1 β (IL-1 β), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) in the amniotic fluid has been known. However, changes of Lf in amniotic fluid with infection has not been reported. In the present study, Lf concentrations in amniotic fluid were measured under the intra-uterine infections state and the biological significance of Lf was investigated. The effects of Lf on the IL-6 and IL-6mRNA production in cultured amnion cells were also investigated. The concentrations of Lf and IL-6 in amniotic fluid with CAM were 8.76±0.65 μg/ml and 6.92±4.88 ng/ml (n=28) respectively and both were significantly higher (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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