| Popis: |
BACKGROUND Prolidase, a member of the matrix metalloproteinase (MMP) family, is a cytosolic imido dipeptidase, which specifically splits imido dipeptides with C-terminal proline or hydroxyproline. We wanted to compare the serum levels of prolidase enzyme activity & total antioxidant status in patients with metabolic syndrome. Increased prolidase activity and decreased total antioxidant status may indicate critical biological activities relevant to pathological events in metabolic syndrome (MetS), and this activity may be a biological indicator of disease. METHODS This cross-sectional study was conducted in the Department of Biochemistry, Veer Surendra Sai Institute of Medical Sciences and Research, Burla. Out of a total of 135 subjects, 45 had metabolic syndrome, 45 were obese without metabolic syndrome and 45 were non-obese healthy controls. RESULTS In MetS group, prolidase levels were significantly higher when compared to obese and control groups (P < 0.001 and P < 0.05 respectively) and also in obese group against control group (P < 0.05). Tacrolimus (TAC) levels were also lesser in MetS and obese groups when compared to those of control group (P < 0.001 and P < 0.05 respectively). Prolidase was negatively correlated with TAC and high density lipoprotein (HDL-C); r = − 0.33, P < 0.1; r = − 0.35, p < 0.08 and positively correlated with body mass index (BMI), waist circumference, systolic blood pressure (SBP), diastolic blood pressure (DBP), triglycerides (TG), total cholesterol (TC), low density lipoprotein (LDL-C) & TOS (r = 0.42, P = 0.03; r = 0.39 P = 0.05; r = 0.40 P < 0.04; r = +0.44, P = 0.02; r = 0.39, P = 0.05; r = 0.41, P = 0.04 and r = 0.4, P = 0.04, respectively. CONCLUSIONS Increased prolidase activity is closely associated with the medical phenotype of the metabolic syndrome. Increased prolidase activity and decreased total antioxidant status may indicate critical biological activities relevant to pathological events in Mets, and this activity may be a biological indicator of disease. |
