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Objective To investigate the influences of mesenteric lymph duct ligation (LDL) on the coagulation function in rats with severe heat stroke (SHS). Methods Forty male Wistar rats were randomly and equally divided into control, heat stroke sham (HSS), HSS-LDL, severe heat stroke (SHS) and SHS+LDL groups. Mesenteric lymph ducts were ligated in HSC-LDL and SHS-LDL groups before reproduction of SHS model. SHS rat models were reproduced in a prewarmed incubator. Peripheral blood was drawn to determine the parameters pertaining to blood coagulability including prothrombin time (PT), activated partial thromboplastin time (APTT), D-dimmer and platelet count (PLT), and lung and kidney histopathology was observed after heat stroke. Results Compared with those in control group, no obvious changes were observed in the coagulation indices in HSS and HSS-LDL group. While PT and APTT significantly prolonged, PLT remarkably decreased, D-dimmer markedly increased in SHS group (P |
