Polymorpnism and multifunctionality of blood group antigens
| Autor: | E A Ryskina, N N Chernov, A A Epifanova, N C Nefedova |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: | |
| Zdroj: | RUDN Journal of Medicine, Vol 0, Iss 4, Pp 31-36 (2011) |
| ISSN: | 2313-0261 2313-0245 |
| Popis: | Group antigens of red blood cells are not only markers of blood groups, but also have different functions: receptor, transport, regulatory, trophic, immune, etc. The human genome has a gene locus ABO, which determines the blood group and regulates synthesis of the corresponding antigens. Genes A and B do not produce antigens directly, and their direct products are enzymes - glycosyltransferases. Transferases are able to attach the respective residues of glucose to the H-antigen galactose, thereby forming antigens A, B or AB. A and B antigens are heterogeneous in their structure and can be manifested in a number of different allotype. The main feature of the ABO system is the presence of natural antibodies to the missing red blood cell's antigen in plasma. In the interaction of antigen with antibody, both compounds exert mutual influence on their own conformation. |
| Databáze: | OpenAIRE |
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