| Popis: |
Background and Design: Sarcoidosis is a multisystemic disorder especially involves the lung, reticuloendothelial system, eyes and skin, characterized with noncaseating granulomatous histopathology with unknown etiology.Although, skin involvement has been reported 9-37% in patients with sarcoidosis, isolated skin involvement has been reported only 5.4-13.8% of the cases. The purpose of this retrospective study was to evaluate the clinical and histopathologic characteristics of patients with sarcoidosis and the relationship of cutaneous sarcoidosis with systemic sarcoidosis.Material and Method: Case records and histopathological files of 27 patients with a clinicopathological diagnosis of cutaneous sarcoidosis at the our Dermatology and Venereology Department from 2005 to 2011 were retrospectively reviewed.Results: A total of patients, 22 patients were female and 5 male. Mean age was 45(12-69). Mean duration of the disease was 1.5 years(1 month to 5 years). Only skin lesions in 30% of the patients, 19 patients(70%) had extracutaneous involvement. The distribution of specific types of skin lesions in sarcoidosis were plaque(12), nodules(10), papules(6), lupus pernio(4) maculopapular(1) and most common localization of the lesions was head and neck region. One patient had an erythema nodosum lesion. Topical and systemic corticosteroids were used in eight patients with isolated skin lesions. Systemic, topical and intralesional corticosteroids and methotrexate were used in patients with extracutaneous involvement. Most of the cases skin lesions were improved in 2-years follow-up period. Relapse was observed in 33% of the patients.Conclusion: Cutaneous involvement can occur as the first sign of systemic disease. According to our study results 30% of our cases characterized with isolated skin involvement. Systemic signs of disease may accompanied in patients with cutaneous sarcoidosis.Therefore, all patients presenting to the dermatology departments with cutaneous sarcoidosis require investigations for systemic sarcoidosis. |
