Changes of ocular fundus hemodynamics and retinal and choroidal thickness after tail suspension for 2 weeks in rats

Autor: Yu-Bo GONG, Hong-Wei ZHAO, Fei-Long SONG, Yu ZHANG, Xiao-Hua GUO, Ling LUO, Yong-Jie XU, Yuan-Yuan SHI
Jazyk: čínština
Rok vydání: 2021
Předmět:
Zdroj: Medical Journal of Chinese People's Liberation Army, Vol 46, Iss 1, Pp 7-10 (2021)
ISSN: 0577-7402
Popis: Objective To investigate the effects of simulated 2-week microgravity on the ocular fundus hemodynamics of central retinal artery and the retinal and choroidal thickness in autogenous rats. Methods Eight healthy SD rats were designed in self-control, designed for the control before tail suspension, the tail suspension for 1, 4, 7 and 14 d. A rat model of simulated microgravity method was established by tail suspension. The peak maximum systolic velocity (PSV) of central retinal artery (CRA) in rats was detected and analyzed by color Doppler ultrasonography. The retinal and choroidal thicknesses were measured by the enhanced depth imaging spectral-domain optical coherence tomography (EDI SD-OCT). Results The PSV value in each different period after tail suspension was decreased compared with that in the control before tail suspension (P0.05), but there was a significant difference between the tail suspension for 1 d and the tail suspension for 14 d (P0.05). The choroidal thickness was lower in the control before tail suspension than that in each different period after tail suspension (P
Databáze: OpenAIRE