TECHNOLOGICAL PARAMETERS OF PRODUCTION OF LIPOSOMES WITH OXALIPLATIN
| Autor: | O. V. Stadnichenko, Yu. M. Krasnopolsky, T. G. Yarnykh |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Фармацевтичний часопис, Vol 0, Iss 1 (2018) |
| ISSN: | 2414-9926 2312-0967 |
| Popis: | The development of medicines of a nanoscale diapason opens a new trend in the modern pharmaceutical industry. Reducing the toxicity of known cytotoxic agents is one of the advantages of the liposomal biotechnology platform. The aim of the work is to offer scientifically grounded technology of production of liposomal form of oxaliplatin based on the experiment. To analyze intermediate products, define control points. Materials and Methods. Egg phosphatidylcholine produced byLipoid,Germany was used to make liposomes. Dipalmitoylphosphatidylglycerin, cholesterol, solvents used by the companySigma-Aldrich,USA. The lipid film was obtained on a rotary evaporator Buchi 210. For homogenization, an extrusion method at high pressure was used. The lyophilization process was carried out on Quarco equipment (PRC). Results and Discussion. The experimental industrial technology of obtaining the liposomal form of oxaliplatin was developed. The development of a full-fledged technology requires the study of colloidal properties of a heterogeneous nano-system, especially at the rehydration stage, lyophilization parameters, validation of control methods for the encapsulation of oxaliplatin into liposomes, validation of quantitative determination and determination of impurities. Conclusions. A new, original technology and control points for obtaining liposomal form of oxaliplatin are proposed. The technology has been tested on batches of preparations, used for preclinical studies. |
| Databáze: | OpenAIRE |
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