| Popis: |
Introduction: The aim of this study was to determine the microbial distribution and antibiotic susceptibility patterns of corneal scrapings isolated from patients with bacterial keratitis. Materials and Methods: The study included a survey of all positive corneal scrapings submitted to the microbiology laboratory over a period of five years (2002-2006) at Hadassah University Hospital. Fungal, protozoal, mycoplasma, and mycobacteria isolates were excluded from this survey. Results: During this five-year period, 259 positive corneal scrapings for presumed bacterial keratitis were reported. Gram-positive organisms were the commonest bacterial isolates. The most common pathogens isolated were Staphylococcus species (n= 104, 40.2%), Pseudomonas aeruginosa (n= 44, 17.0%), Streptococcus species (n= 31, 12.0%), and Propionibacterium species (n= 22, 8.5%). There were 218 adults and 41 children. The microbiological survey showed no differences in the main bacterial isolates from corneal scrapings between children and adults. Gram-positive bacteria were sensitive to vancomycin (100%), ceftriaxone (100%), rifampicin (98.2%), teicoplanin (97.6%), and ofloxacin (90.9%), while gram-negative bacteria were sensitive to ceftazidime (100%), ceftriaxone (100%), meropenem (100%), ciprofloxacin (98.6%), piperacillin-tazobactam (98.2%), aztreonam (98.2%), ofloxacin (97.1%), amikacin (97.1%), and gentamicin (94.3%). Conclusion: Staphylococcus species were determined as the most common causative organism for bacterial keratitis. Gram-positive susceptibility was highest for vancomycin, teicoplanin and ofloxacin, while gram-negative bacterial susceptibility was highest for ceftazidime, ceftriaxone and meropenem. |
