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Objective To observe the therapeutic effect of soybean isoflavone on high altitude polycythemia (HAPC). Methods At an area of above 5000m altitude, 38 patients clinically diagnosed as HAPC were orally administered soybean isoflavone capsule in 20mg/time, 2 times/d for three months. Before and after administration, the clinical manifestations of all the patients were observed, and ultrasonic cardiography was used to evaluate right ventricular end-diastolic dimension (RVED), right ventricular anterior wall (RVAW), right ventricular outflow tract (RVOT) and main pulmonary artery diameter (MPA). Heart rate (HR), arterial oxygen saturation (SaO2), hemoglobin (Hb), hematocrit (Hct), superoxide dismutase (SOD) and malonaldehyde (MDA) were determined, and the six-minute walk test (6MWT) was performed. Results After treatment, Hb, Hct, RVED, RVAW, RVOT, MPA and MDA declined significantly (P |
