| Autor: |
Mehtap Gökçe, Berrin Özçelik, Yakut Akyon, Erdogan Berçin, Ningur Noyanalpan |
| Jazyk: |
angličtina |
| Rok vydání: |
2004 |
| Předmět: |
|
| Zdroj: |
Turkish Journal of Pharmaceutical Sciences, Vol 1, Iss 1, Pp 55-64 (2004) |
| ISSN: |
2148-6247 |
| Popis: |
In this study, anti-Helicobacter pylori activity of previously synthesized 1-[(2-animophenyl)thio]-1-phenyl-2-nitroethane 1 and 1-[(2-aminophenyl]-1-phenyl-2-nitropropane 2 derivatives has been examined. Anti-Helicobacter pylori activity of these compounds was investigated in-vitro agar dilution method. Ampicillin and ofloxazin were used as references. According to the results anti-Helicobacter pylori activities of the compounds are not close to that of ampicillin and ofloxazin. However, compound 1b was found as having a comparable activity to reference compounds. Özet Bu çalismada sentezleri daha önceden yapilan 1-[(2-aminofenil)tiyo]-1-fenil-2-nitroetan 1 ve 1-[(2-aminofenil)tiyo]-1-fenil-2-nitropropan 2 türevlerinin anti-Helicobacter pylori aktivileri test edilmistir. Bilesiklerin anti-Helicobacter pylori aktiviteleri in-vitro agar dilution metodu ile arastirilmistir. Ampisilin veofloksazin referans bilesikler olarak kullanilmistir. Sonuçlara göre bilesiklerin anti-Helicobacter pylori aktivitesi ampisilin ve ofloksazine yakin degildir. Buna ragmen 1b bilesigi referans bilesiklerle kiyaslanabilir aktiviteye sahip bulunmustur |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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