| Popis: |
Objective: To investigate the effects of general anesthesia combined with epidural anesthesia on stress response, inflammation level and coagulation function in patients undergoing laparoscopic colon cancer resection during intraoperative and postoperative. Methods: A total of 98 patients undergoing colon cancer radical surgery in our hospital from August 2015 to August 2017 were randomly divided into control group and observation group with 49 cases in each group. In the control group, systemic intravenous anesthesia was used; and in the observation group, a systemic intravenous anesthesia combined epidural anesthesia was used. Serum of venous blood was collected from patients before anaesthesia, 30 min after anesthesia, and two hours after operation to detect stress response indexes, such as adreno-cortico-tropichormone (ACTH), adrenaline (AD), norepinephrine (NE) and cortisol (Cor), and inflammatory response indexes, such as tumor necrosis factor-α (TNF-α), procalcitonin (PCT) and C-reaction protein (CRP). Venous blood was collected at the same time points for coagulation testing. Functional indicators such as prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT) and fibrinogen (FBG) were detected. Results: There was no significant difference in the level of each index between the two groups before anesthesia. At 30 minutes after anesthesia and at 2 hours after operation, the stress response indicators and inflammatory response indicators in the observation group were lower than those in the control group at the same time points; apart of the blood coagulation function indexes (PT, APTT and TT) in the observation group were higher than the corresponding indicators of the control group at the same time points, but the FBG content in the observation group was lower than that of the control group at the same time points, and these differences were significant. Conclusion: The method of general anesthesia combined with epidural anesthesia can effectively reduce the stress and inflammatory reaction during and after operation of laparoscopic colon cancer resection, and reduce the abnormal coagulation function as well as the blood hypercoagulability. |
