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Haimeng Yan,1 Donghua He,1 Weijia Huang,1 Fei Chen,1,2 Jingsong He,1 Zhen Cai,1,3,4 Yi Zhao1 1Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China; 2Department of Hematology, Haining People’s Hospital, Haining, People’s Republic of China; 3Institute of Hematology, Zhejiang University, Hangzhou, Zhejiang, People’s Republic of China; 4Zhejiang Laboratory for Systems & Precision Medicine, Zhejiang University Medical Center, Hangzhou, 311121, People’s Republic of ChinaCorrespondence: Yi Zhao; Zhen CaiBone Marrow Transplantation Center, Zhejiang University School of Medicine, Qingchun Road 79, Hangzhou, 310009, People’s Republic of ChinaEmail zhaoyi999@zju.edu.cn; caiz@zju.edu.cnBackground: Acute promyelocytic leukemia differentiation syndrome (APL DS) is a common and severe complication seen in patients with APL treated with all-trans retinoic acid (ATRA) and/or arsenic trioxide (ATO). The presenting symptoms of APL DS are diverse, and rare symptoms are easy to be misdiagnosed. Therefore, it is very crucial to identify DS from uncommon signs to avoid delay in treatment.Case Presentation: Here, we report a patient of APL who developed severe abdominal pain during ATRA and ATO therapy, with increasing leukocyte count. Organic diseases were firstly excluded, and empiric treatment for DS was adopted. The abdominal pain was gradually relieved and the patient eventually achieved complete remission.Conclusion: This case history suggests that APL DS may manifest as severe abdominal pain, and the early identification of DS and immediate treatment could improve the prognosis of patients.Keywords: acute promyelocytic leukemia, all-trans-retinoic acid, arsenic trioxide, differentiation syndrome, abdominal pain, case report |
