| Popis: |
Allergic airway inflammation is manifested as infiltration of CD4+ T cells and eosinophils in the airway, increased secretion of mucus, airway hyper-reactivity and airway remodeling. IL-25 is a member of the IL-17 family, which can promote and exacerbate Th2 cytokine-mediated airway inflammation after binding to its receptor IL-17RB. The increased IL-25 can induce the secretion of Th2 cytokines, including IL-4, IL-5 and IL-13, which may result in the local infiltration of eosinophils, airway hyperreactivity and therefore the injury of airway. As IL-25 plays an important role in allergic airway inflammation, the present paper would focus on the relationship between IL-25 and allergic airway inflammation. DOI: 10.11855/j.issn.0577-7402.2017.11.02 |
