| Autor: |
Di TIAN, Ya-fei QIN, Ru YING, Ying TAN, Li FENG, Yong YUAN, Wen-yan LAI, Zhi-gang GUO |
| Jazyk: |
čínština |
| Rok vydání: |
2013 |
| Předmět: |
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| Zdroj: |
Medical Journal of Chinese People's Liberation Army, Vol 38, Iss 3, Pp 195-200 (2013) |
| ISSN: |
0577-7402 |
| Popis: |
Objectives To investigate the effect of simvastatin on anti-oxidation and anti-inflammation properties of high density lipoprotein (HDL) in apoE-/-mice fed with high-fat diet. Methods Eighteen 8-week old male C57BL/6J mice as blank control group were fed with normal diet, and thirty 8-week old male apoE-/-mice were fed with high-fat diet. Four weeks later, 6 mice in each group were sacrificed. The remaining 24 apoE-/-mice were randomly divided into two groups (12 each): atherosclerosis group (AS group) and simvastatin group, while the remaining 12 C57BL/6J mice served as control group. The mice in both control and AS group were fed with the original diet, and the mice in simvastatin group were fed with the same high-fat diet plus simvastatin 5mg/ (kg.d). At the end of the 8th and 16th week, 6 mice were sacrificed in each group. Serum lipid levels, paraoxonase 1 (PON1) activity (arylesterase activity), serum myeloperoxidase (MPO) activity, high-density lipoprotein inflammation index (HII) and serum hs-CRP levels were determined. The atherosclerotic lesion formation in the aorta was manifested by oil red O staining. Results At the end of the 8th week, no difference was found in the levels of serum low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) between simvastatin and AS group. At the end of 16th week, the levels of serum LDL-C decreased significantly (P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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