Unexplained High Activity of Aspartate Aminotransferase in an Asymptomatic Pediatric Patient
| Autor: | Wajiha Maan, Qurratul Ann Warsi, Avideh Rashed, Manoochehr Karjoo |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | International Journal of Pediatrics, Vol 5, Iss 10, Pp 5805-5808 (2017) |
| ISSN: | 2345-5055 2345-5047 |
| Popis: | Elevated enzyme activities in plasma may at times be attributed to the presence of macro-enzymes. The macro-enzymes are often serum enzymes in complex with immunoglobulins, resulting in a greater molecular mass that cannot be filtered by renal glomeruli and are, hence, retained in the plasma. The aspartate aminotransferase (AST) can exist as a macro-enzyme, although it has been rarely reported. We describe a pediatric patient with persistently elevated serum AST activity, due to macro-enzyme formation between AST and an immunoglobulin. This is to highlight the importance of early diagnosis of macro-AST in an otherwise asymptomatic pediatric patient with isolated AST-elevation and to avoid unnecessary costly testing. |
| Databáze: | OpenAIRE |
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