| Popis: |
Objective: To study the changes of long-term recurrence, metastasis and blood indexes after sustained-released fluorouracil implantation in radical operation for colon cancer. Methods: A total of 92 patients who received radical operation for colon cancer in our hospital from May 2009 to March 2011 were selected and divided into two groups, observation group received complete mesocolic excision combined with intraoperative sustained-released fluorouracil implantation + postoperative FOLFOX4 chemotherapy, control group accepted complete mesocolic excision + postoperative FOLFOX4 chemotherapy, tumor recurrence and metastasis were followed up, and serum tumor marker and adverse reaction index levels as well as the stem cell marker levels in recurrent lesions were determined. Results: Postoperative 3-year and 5-year overall survival and progression-free survival of observation group were higher than those of control group while local recurrence rate and liver metastasis rate were lower than those of control group; adverse reaction indexes GM-CSF, G-CSF, TBIL, TBA, CysC and β 2-MG were not significantly different between two groups one week after operation; serum tumor markers CEA, CA199, CA153, HGF, CCSA-2 and VEGF levels of observation group 1 year after operation were significantly lower than those of control group, and CD44, Lgr5, Nanog, Oct-4 and SOX-2 levels in recurrent lesions were lower than those of control group. Conclusions: Sustained-released fluorouracil implantation in radical operation for colon cancer can reduce long-term recurrence rate and metastasis rate of colon cancer and inhibit the characteristics of tumor stem cells without increasing adverse reaction. |
