Efectos del D-005, extracto lipídico del fruto de Acrocomia Crispa, sobre el estrés oxidativo inducido por tetracloruro de carbono en ratas
| Autor: | Ambar Oyarzábal Yera, Yohani Pérez Guerra, Sonia Jiménez Despaigne, Vivian Molina Cuevas |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Revista CENIC. Ciencias Biológicas, Vol 52, Iss 2, Pp 137-145 (2021) |
| ISSN: | 2221-2450 0253-5688 |
| Popis: | Oxidative stress is produced by the imbalance between the substances or factors pro-oxidant and the antioxidant defense mechanisms, which in turn plays an important role in the development and progression of various pathologies. D-005, lipid extract from the fruits of Acrocomia crispa contains a reproducible mixture of fatty acids, such as: oleic, palmitic, lauric, myristic, palmitoleic, caprylic, capric, and stearic that have antioxidant properties. The objective of this work is to evaluate the effect of D-005 administered as single oral doses on the increase in indicators of oxidative stress induced by carbon tetrachloride (CCl4) in rats. The animals were randomly distributed into seven groups: a negative control without damage and six groups to which CCl4 was administered (intraperitoneal): a positive control treated with vehicle, four with D-005 (5-100 mg/kg), and one with grape seed extract (ESU) (250 mg/kg). The animals in the positive control group (with CCl4) reached significantly higher values of malondialdehyde-marker of lipid peroxidation-, sulfhydryl groups-marker of protein oxidation- and serum transaminases-marker of liver damage- with respect to the animals of the negative control group (without damage). D-005 and ESU markedly and significantly prevented this increase. In conclusion, D-005 administered as single oral doses of 5, 25, 50, and 100 mg/kg inhibits lipid peroxidation and protein oxidation, as well as CCl4-induced liver damage. |
| Databáze: | OpenAIRE |
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