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Qiang-Hua Jiang,1,* Hong-Xin Peng,2,3,* Yi Zhang,4 Peng Tian,4 Zu-Lian Xi,4 Hao Chen4 1Department of Surgery, Dongyang People’s Hospital, Dongyang, Zhejiang, 2Medical College, Southeast University, 3Central Laboratory, Nanjing First Hospital, Nanjing, Jiangsu, 4Hubei Key Laboratory of Biological Targeted Therapy, Yichang Yiling Hospital, Yichang, Hubei, People’s Republic of China *These authors contributed equally tothis work Abstract: rs712 within 3'-untranslated region of KRAS can affect the specific binding between the mRNA and its targeted microRNAs, leading to the activation of KRAS oncogene. However, the possible association between the locus and susceptibility to colorectal cancer (CRC) remains unclear. We investigated genotypes of the locus in 586 cases and 476 controls to explore the possible association between them. Results of our case–control study showed that genotypes TT (6.5% vs 2.5%, P=0.002, adjusted odds ratio [OR] =2.810, 95% confidence interval [CI] =1.342–5.488) and GT/TT (36.5% vs 30.5%, P=0.038, adjusted OR =1.342, 95% CI =1.030–1.712) and allele T (21.5% vs 6.5%, P=0.004, adjusted OR =1.328, 95% CI=1.105–1.722) of rs712 were significantly associated with an increased risk of CRC, and the significant association was also observed in the recessive model (TT vs GG/GT, 6.5% vs 2.5%, P=0.003, adjusted OR =0.372, 95% CI =0.191–0.725). However, there was no association between genotype GT and risk of CRC (30.0% vs 28.0%, P=0.235, adjusted OR =1.210, 95% CI=0.903–1.548). Furthermore, genotype GT (P=0.003) and allele T (P=0.003) were significantly associated with poor differentiation, and genotypes GT and TT and allele T were significantly associated with tumor-node-metastases stage III (P=0.001 for GT vs GG, P |
