| Popis: |
The developed method of synthesis of 2-methoxy-3-aryl(hetaryl)propanola by organocatalysis the crossaldol condensation of aromatic or heteroaromatic aldehydes with matosiuk-sonnym aldehyde under microwave activation. In the syntheses were used the microwave reactor Anton Paar Monowave-300. Effective organocatalysts selected pyrrolidine (30-100 mol%), commonly used in fine organic synthesis. Advantages of this method are the absence of toxic solvents, short reaction time (1-3 min), a simple treatment of the reaction mixture. However, the yields of target products remain moderate (47-53%). Obtained new representatives of a,b unsaturated aldehydes - 2-methoxy-3-phenylpropenal and 2-methoxy-3-(2-furyl)propenal – promising objects for further studies. For example, these compounds may be of interest as starting reagents in the synthesis of heterocyclic compounds (pyrroles, oxazolidines, pyrazoles, imidazolidine,. etc.). |
