The illustration of the successful mobilization of hematopoietic stem cells using plerixafor and pegfilgrastim in the patient with non-hodgkin's lymphoma
| Autor: | M S Motalkina, S A Kulyova, S M Alexeev, I S Zuzgin, L V Filatova, A S Zhabina, A A Zverkova, I V Ishmatova, A A Rjazankina, A S Artemyeva, T Yu Semiglazova |
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| Jazyk: | ruština |
| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | Современная онкология, Vol 17, Iss 2, Pp 54-56 (2015) |
| ISSN: | 1815-1442 1815-1434 |
| Popis: | In our clinical example, we studied the possibility of early treatment intensification, through the use of a new combination pegfilgrastim and plerixafor as a regime of mobilization. Within 4 days (after a single injection pegfilgrastim 6 mg in D1) we observed a gradual increase in the content of CD34+-cells in peripheral blood, but only after injection plerixafor (D4) at a rate of 0.24 mg/kg, we were able to initiate the apheresis procedure. Number of collected CD34+-cells was 14,9106 that is more than adequate for a quick and stable hematopoietic recovery after a course HDC and timely recovery of the cellular composition of the blood of this patient (D10) indicated the quality of hematopoietic assembled material. Thus, the combination pegfilgrastim and plerixafor - a simple and effective way to mobilize hematopoietic stem cells in peripheral blood. |
| Databáze: | OpenAIRE |
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