| Autor: |
Hua-sheng TONG, Peng-kai DUAN, Xing-Qin ZHANG, Xiao-qing AN, Peng WAN, You-qing TANG, Lei SU |
| Jazyk: |
čínština |
| Rok vydání: |
2014 |
| Předmět: |
|
| Zdroj: |
Medical Journal of Chinese People's Liberation Army, Vol 39, Iss 10, Pp 791-794 (2014) |
| ISSN: |
0577-7402 |
| Popis: |
Objective To explore the effect of mesenteric lymph from rats suffering from heat stroke (SHS) on the inflammatory activity of vascular endothelial cells. Methods Rats were placed in a prewarmed incubator to reproduce heat stroke. Human umbilical vein endothelial cells (HUVECs ECV-340) were incubated in 5% mesenteric lymph collected pre-, during-, and post-HS for 3 and 6 h respectively in vitro. The levels of high mobility group protein B1 (HMGB1), tumor necrosis factor α (TNF-α), interleukin 1β (IL-1β), and IL-6 of ECV-340 cells were determined. The expression of intercellular adhesion molecule 1 (ICAM-1) mRNA and NF-κB activity of ECV-340 were also assayed. Results The levels of HMGB1, TNF-α, IL-1β and IL-6 induced by SHS mesenteric lymph of rats significantly increased after heat treatment (P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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