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Objective: To investigate the clinical effect of mifepristone combined with loose joint capsule on the treatment of endometriosis (EMS) and its effect on sex hormone levels. Methods: A total of 140 cases of EMS in our hospital from Feb 2015 to Feb 2016 were selected and randomly divided into treatment group and control group; Control group in menstrual cramps on the 5th day oral mifepristone 12.5 mg each time, once daily, and even served 3 months, the treatment group in the control group based on the combined with Sanjie Zhentong capsule 1.6 g/ time, 3 times daily, even served three months; Acquisition of two groups of patients before treatment and after treatment in the morning fasting venous blood, using ELISA method for the detection of two groups before and after treatment serum follicle stimulation hormone (FSH), luteinizing hormone (LH), estradiol (E2), and progesterone (P) and adiponectin (ADP) and hepatocyte growth factor (HGF) and observe the incidence of clinical adverse reactions in two groups. Results: FSH, LH, E2 and P levels in the two groups after treatment than before treatment was significantly lower, the treatment group after treatment FSH, LH, E2 and P levels was significantly lower than that of the control group; after treatment in the two groups was increased compared with before treatment, the level of ADP and HGF treatment level is decreased, the treatment group after treatment level of ADP and HGF improved better than control group. Treatment of adverse reactions in the treatment group was lower than control group. Conclusions: Mifepristone combined with scattered knot analgesia capsule can regulate sex hormone level in patients with EMS and inhibit the growth of ectopic endometrium, and decrease the recurrence rate and improve the pregnancy rate. |
