| Autor: |
Hui LI, Chun-xiao LI, Peng NAN, Ting WANG, Jin-song WANG, Jing-yao ZHANG, Na DOU, Fei MA, Hai-juan WANG, Hai-li QIAN, Qi-min ZHAN |
| Jazyk: |
čínština |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
Medical Journal of Chinese People's Liberation Army, Vol 43, Iss 3, Pp 217-223 (2018) |
| ISSN: |
0577-7402 |
| Popis: |
Objective To analyze and validate the key molecular targets correlated with the overall survival of patients with HER2-positive breast cancer. Methods First, the survival time and transcriptome data of patients with HER2-positive breast cancer in stage Ⅰ/Ⅱ and Ⅲ/Ⅳ were downloaded from the TCGA database. The significantly differential genes between overall survival 8.5 years in stage Ⅰ/Ⅱ were picked out by edgeR package, and the pathways were enriched by KEGG. Similarly, the differential genes between overall survival 7 years in stage Ⅲ/Ⅳ were analyzed. Furthermore, KEGG pathway analysis was performed using the differential genes overlapped by stage Ⅰ/Ⅱ and Ⅲ/Ⅳ. Second, the relationships between the expression levels of key node genes and other genes in enriched pathway and the overall survival of patients with HER2-positive breast cancer were validated by KMplot database. Last, the correlation between the activity of pathway enriched in KEGG and the resistance to anti-HER2 treatment was validated in HER2-positive breast cancer cell line BT474. Results In patients with stage Ⅰ/Ⅱ HER2- positive breast cancer whose overall survival was |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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