On rheological properties erythrocyre at sick of the arterial hypertension with dyslipidemia
| Autor: | I N Medvedev, I А Skorjatina |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: | |
| Zdroj: | RUDN Journal of Medicine, Vol 0, Iss 2, Pp 29-36 (2011) |
| ISSN: | 2313-0261 2313-0245 |
| Popis: | Purpose: comparative investigation of the influence of several inhibitors hydroxymethylglutaril coenzyme A-reductase - Fluvastatin, Lovastatin and Simvastatin on rheological properties of erythrocytes in patients with arterial hypertension and dyslipidemia. The total number of examined and treated patients was 95. Arterial hypertension 1-2 degrees, risk 3 and dyslipidemia II type (recommendation VNOK, 2007) was revealed in all patients The average age of patients was 52,4 ± 2,6 years. The control group consisted of 26 healthy people of similar age. Patients have been divided into 3 comparable, homogeneous groups and were administered either Fluvastatin or Lovastatin or Simvastatin for 12 months in each group. Prescription of Fluvastatin and Lovastatin to patients with arterial hypertension and dyslipidemia for 1 year may reduce the activity of lipid peroxidation in erythrocyte membranes, its deformation changes and aggregation activity whereas one-year therapy by Simvastatin allows the erythrocyte's activity to reach the values of the control group. |
| Databáze: | OpenAIRE |
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