| Popis: |
Objective: To analyze the effect of Fuzheng Xiaoliu decoction combined with paclitaxel treatment of advanced breast cancer on the prognosis as well as tumor marker levels, immune function and so on. Methods: A total of 40 patients with advanced breast cancer were randomly divided into observation group and control group (n=20), control group received conventional chemotherapy + paclitaxel treatment and observation group received conventional chemotherapy + paclitaxel + Fuzheng Xiaoliu decoction treatment. The survival of two groups of patients was followed up, and serum levels of tumor markers and sex hormones as well as immune function indexes were determined. Results: Progression-free survival and overall survival of observation group were longer than those of control group; after one course of treatment, serum VEGF-A, TK1, IGF-1, CerbB-2, CEA, CA15-3, CA125, E1 and E2 levels of observation group were significantly lower than those of control group while LH and FSH levels were significantly higher than those of control group; CD3+ CD4+ , CD8+ CD28+ , CD19+ and CD16+ CD56+ expression levels in peripheral blood of observation group were significantly higher than those of control group while CD4+ CD25+ and CD8+ CD28- expression levels were significantly lower than those of control group. Conclusion: Fuzheng Xiaoliu decoction combined paclitaxel treatment of advanced breast cancer can reduce tumor malignancy and improve the body's immune function, and is of positive significance in optimizing treatment prognosis. |
