| Autor: |
Hong-zhen QIN, Xi-ru LI, Jun-xin ZHANG, Qi-nong YE, Yi-qiong ZHENG, Rong LI |
| Jazyk: |
čínština |
| Rok vydání: |
2011 |
| Předmět: |
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| Zdroj: |
Medical Journal of Chinese People's Liberation Army, Vol 36, Iss 9, Pp 916-917 (2011) |
| ISSN: |
0577-7402 |
| Popis: |
Objective To investigate the changes in the expression of four and a half LIM domains 1(FHL1) in breast neoplasm after neo-adjunct chemotherapy(NCT),and its clinical significance.Methods Expression of FHL1 in breast cancer before and after NCT(with docetaxel combined pirarubicin) was detected by immunohistochemical technique in 76 patients with breast neoplasm.Specimens of 69 cases had received NCT before,of them 63 cases were finally enrolled in present study,among them the specimens were obtained from 59 cases for cohort study.The positive rate and expression intensity of FHL1 before and after NCT were analyzed.Results The positive rate of FHL1 in breast cancer was 79.7% before chemotherapy and 65.1% after chemotherapy.The expression of FHL1 was up-regulated in 17 patients,down regulated in 30 patients,and remained unchanged in 12 patients.The matched pair test showed that the expression of FHL1 significantly down regulated after NCT(P < 0.05).Conclusion NCT may down regulate the expression of FHL1,which may play a harmful effect on the prognosis of a part of patients with breast cancer. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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