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Objective To observe the pathogenesis of motion sickness with different frequencies and accelerations of heave motion. Methods Sixty-four adult male healthy rats were randomly divided into four groups (n=16): Vertical motion mode A (frequency 0.20 Hz, acceleration 0.05 g), vertical motion mode B (frequency 0.40 Hz, acceleration 0.13 g), vertical motion mode C (frequency 0.80 Hz, acceleration 0.48 g) and static control group. The severity of motion sickness was evaluated by three indicators: Frequency of conditioned gaping (nausea like reaction), number of defecation particles and spontaneous activity. Thirty-six male healthy volunteers were randomly divided into four groups (n=9): Vertical motion mode Ⅰ (frequency 0.42 Hz, acceleration 0.22 g), vertical motion mode Ⅱ (frequency 0.42 Hz, acceleration 0.44 g), vertical motion mode Ⅲ (frequency 0.30 Hz, acceleration 0.33 g), and vertical motion mode Ⅳ (frequency 0.25 Hz, acceleration 0.44 g). A modified version of motion-sickness susceptibility questionnaire (MSSQ) was used to evaluate the susceptibility to motion sickness before the test, and Graybiel motion sickness scale to evaluate the severity of motion sickness during the test. MATLAB software was used to establish a population test mathematical model and draw a trend chart. Results Compared with the static control group, rats receiving mode A stimulation did not show significant symptoms of motion sickness, and both the number of conditioned gaping and the number of defecation particles in the vertical motion group B and the vertical motion group C significantly increased, while the spontaneous locomotion activity was significantly reduced after the motion sickness stimulation (P |
