Relationship between serum lipid level and the risk of cervical disc herniation: A case-control study
Autor: | Qian-qian WANG, Cheng-ai WU, Yan-zhuo ZHANG, Yue YUAN, Dan-hui ZHAO |
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Jazyk: | čínština |
Rok vydání: | 2014 |
Předmět: | |
Zdroj: | Medical Journal of Chinese People's Liberation Army, Vol 39, Iss 8, Pp 628-631 (2014) |
ISSN: | 0577-7402 |
Popis: | Objective To assess the relationship between the lipid level and the risk of cervical disc degeneration. Methods A standardized case-control study of cervical disc herniation was formulated. One hundred and one patients with cervical disc herniation, and 102 patients with wounded limbs as control were admitted to Beijing Jishuitan Hospital from January 2012 to May 2013. The data of demographics, history of hypertension and type 2 diabetes, smoking and drinking habit were collected from all the patients. At the time of hospitalization, levels of total cholesterol, triglyceride, low-density lipoprotein (LDL) cholesterol and highdensity lipoprotein (HDL) cholesterol in fasting blood were measured by automatic biochemical analyzer in all patients, and the group matched case-control study was performed to assess the relationship between the lipid level and cervical disc degeneration. Results No differences were found in gender and age between cases and controls. Compared with controls, the levels of total cholesterol and triglyceride were significantly higher in the patients, with the values of 4.88mmol/L vs 4.47mmol/L (P=0.002) and 1.89 mmol/L vs 1.28mmol/L (P=0.003), respectively. Triglyceride level was significantly correlated with cervical disc degeneration after adjustment for multiple covariates through logistic regression. The summary odds ratio (95% confidence interval) per 1mmol/L increase of triglyceride was 1.90(1.25, 2.90), and that of triglyceride was an independent predictive factor for cervical disc herniation after adjustment of total cholesterol and triglyceride levels. Conclusion Elevated triglyceride level may increase the risk of cervical disc herniation. However, more evidences are needed to validate the cause and effect. DOI: 10.11855/j.issn.0577-7402.2014.08.07 |
Databáze: | OpenAIRE |
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