Circadian secretion patterns of ß-endorphin and leucine enkephalin
| Autor: | E. H. de Wet, J. M. C. Oosthuizen |
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| Jazyk: | afrikánština |
| Rok vydání: | 1992 |
| Předmět: | |
| Zdroj: | South African Journal of Science and Technology, Vol 11, Iss 1, Pp 20-23 (1992) |
| ISSN: | 2222-4173 0254-3486 |
| Popis: | ß-endorphin and leucine enkephalin are neuropeptides with potent opioid activity. In a study to investigate the circadian secretion patterns of the above-mentioned, blood samples were collected hourly from 12 healthy males who were subjected to the experiment for 24 hours. Radioimmunoassays were used in the analysis of plasma samples for ß-endorphin and leucine enkephalin. Peak concentrations of ß-endorphin were demonstrated from 08:00-09:00, while peak concentrations of leucine enkephalin occured from 23:00-07:00. Trough concentrations of ß-endorphin occurred from 24:00-05:00, while trough concentrations of leucine enkephalin were demonstrated from 09:00-12:00. The illustrated circadian secretion pattern for ß-endorphin simulates the well-known circadian rhythm of cortisol. The answer to this may be in the fact that ß-endorphin and corticotropin stem from the same precursor. The illustrated circadian secretion pattern for leucine enkephalin simulates that of melatonin. The reason for this is unclear. |
| Databáze: | OpenAIRE |
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